PIK3CA-related overgrowth spectrum (PROS) and Proteus syndrome are extremely rare conditions characterized by localized overgrowths that can affect virtually any tissue and organ (Doucet et al., 2016; Keppler-Noreuil et al., 2014, 2015; Kurek et al., 2012; Lindhurst et al., 2011, 2019; Venot et al., 2018). This evidence concerns the gene PIK3CA and Proteus syndrome.