MLKL and precursor B-cell acute lymphoblastic leukemia: We also confirm the nonapoptotic necrosis mechanism of Cmpd10357 in B-ALL cells involving nuclear translocation of apoptosis-inducing factor (AIF), without activation of caspase 3/7, endoplasmic reticulum (ER) stress, or mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis.