In a patient setting, the activation of the Wnt/β-catenin–TCF axis was found to be significantly lower in the CD133+ colon CSC-like population and its inhibition led to a boost in tumour growth in mouse xenografts (Horst et al., 2012; Chen et al., 2021b; Varnat et al., 2010; Kramer et al., 2017). The gene discussed is HNF4A; the disease is neoplasm.