These results suggest that the inflammatory response induced by HMGB1 aggravates SAP-ALI, whereas DCQD reduces the translocation of HMGB1 to the lung through the intestinal lymphatic pathway, reduces the binding with RAGE, inhibits the NF-κB p65 signalling pathway and reduces the release of various cytokines, such as TNF-α, IL-1β and IL-6, which plays an important role in the treatment of SAP-ALI. This evidence concerns the gene AGER and acute respiratory distress syndrome.