Moreover, lncRNA IGFL2-AS1 also plays an oncogenic role in tongue squamous cell carcinoma and basal-like breast cancer.9,29 Moreover, increased lncRNA IGFL2-AS1 is associated with the tumor-node-metastasis staging of colon cancer and renal cell carcinoma.7,30 Altogether, our findings and shreds of evidence suggested that lncRNA IGFL2-AS1 is upregulated in CRC tissues and cells and plays a driving role in HCT116 cell malignant proliferation. The gene discussed is IGFL2; the disease is tongue squamous cell carcinoma.