IGFL2 and colorectal carcinoma: Moreover, qRT-PCR showed that miR-433-3p was weakly expressed in CRC tissues and cells, miR-433-3p was both markedly increased in the si-IGFL2-AS1-1 and si-IGFL2-AS1-2 groups compared with the si-NC group and markedly declined in the oe-IGFL2-AS1 group compared with the oe-NC group (P  < .05, Figure 3F), and miR-433-3p was negatively correlated with lncRNA IGFL2-AS1 in CRC tissues (P  < .05, Figure 3G).