Genetic alterations participate in cancer cell behaviors, such as proliferation, migration, invasion, and apoptosis.25 Exploring the ceRNA network of lncRNA/miRNA/mRNA helps to better understand the molecular etiology of CRC and provides therapeutic targets in clinic management.26,27 In the current study, our findings unveiled that lncRNA IGFL2-AS1 comparatively binds to miR-433-3p to facilitate PAK4 transcription, thus promoting HCT116 cell malignant proliferation. The gene discussed is IGFL2; the disease is cancer.