In line with these, the oncogenic property of PAK4 was also manifested in breast cancer, bladder cancer, pancreatic cancer, and lung cancer.38-41 Above all, PAK4 overexpression partly reversed the inhibition of silencing lncRNA IGFL2-AS1 on HCT116 cell malignant proliferation. The gene discussed is IGFL2; the disease is urinary bladder cancer.