IGFL2 and colorectal carcinoma: PAK4, an oncoprotein that overcomes oncogene-induced senescence, shows upregulation in CRC and encourages CRC cell proliferation, migration, and invasion and tumor growth.17-19,37 To investigate the role of PAK4 in CRC, PAK4 was overexpressed in HCT116 cells in the si-IGFL2-AS1 group via oe-PAK4, and we observed that PAK4 overexpression augmented cell viability and clone number.