miRNA, as a critical player in the ceRNA regulatory network, regulates CRC progression, metastasis, and therapeutic resistance and links with risk factors related to oncogenesis in CRC, such as obesity and insulin resistance.31-33 Of note, miR-433 was previously found to be decreased in CRC and suppress CRC cell motility.14,15,34 We confirmed the binding relationship between lncRNA IGFL2-AS1 and miR-433-3p via the database prediction, RIP, and dual-luciferase reporter gene assays. Here, IGFL2 is linked to obesity due to melanocortin 4 receptor deficiency.