In fact, it was shown that TCS1102, another DORA is more efficacious at reducing stress-induced reinstatement of alcohol-seeking behavior in rats with a history of alcohol dependence (Matzeu and Martin-Fardon, 2020; Flores-Ramirez et al., 2022), strongly supporting the beneficial effects of targeting both OrxR1 and OrxR2 to prevent stress-induced craving and relapse in individuals suffering form AUD. The gene discussed is HCRTR2; the disease is alcohol dependence.