In the present study, NVHL rats, which also exhibit schizophrenia-like behaviors (Sams-Dodd et al., 1997; Becker et al., 1999; Mitazaki et al., 2020), showed significant reduction in NRG-1 and p-erbB4 levels in the PFC (Figures 2, 3), suggesting that NRG-1/erbB4 pathway in the PFC of NVHL rats was impaired. This evidence concerns the gene NRG1 and schizophrenia.