Moreover, mutant mice carrying mutations in the NRG-1 or erbB4 gene show schizophrenia-like behaviors such as disruption of PPI, latent inhibition and cognitive deficits (Stefansson et al., 2002; Falls, 2003; Hashimoto et al., 2004; Rimer et al., 2005; O’Tuathaigh et al., 2007). This evidence concerns the gene NRG1 and schizophrenia.