Still in that sense, considering the participation of IDH1/2 in GBM neoangiogenesis, via the HIF-1a pathway and in the promotion of oncogenesis via the 2HG pathway, as evidenced by Verhaak, it may suggest that the action of IR on NS interrupts its quiescence, making it favorable to gliomagenesis and neoangiogenesis [21]. The gene discussed is HIF1A; the disease is glioblastoma.