SOX2 and glioblastoma: According to Morgado et al., cell hypoxia injuries alter the GBM stem cells microenvironment, interrupting its quiescence and favoring its differentiation and invasion into adjacent tissue, and one of the miRNAs implicated in this process is miR-145, which becomes overexpressed, reducing the Sox2 and Lin28/let7 pathway, besides increasing the expression of let-7a and let-7b in process of gliomagenesis in GBM stem cells [30].