CD40LG and rheumatoid arthritis: A logistic regression revealed that anti-LtxA IgM levels were associated with RA during early disease (OR 1.012, 95%CI 1.007, 1.017), which was maintained after adjustments were made for smoking, anti-CCP antibodies, rheumatoid factor, HLA-DRB1 shared epitope alleles, and sex [26].