CHB: Chronic hepatitis B, NA: Nucleotide analog, HBsAg: Hepatitis B surface antigen, HCC: Hepatocellular carcinoma, IL-21: Interleukin 21, TDF: Tenofovir disoproxil fumarate, PEG-IFN: Pegylated interferon , FASGL: Fas ligand, CCL4: Chemokine ligands 4. This evidence concerns the gene IL21 and hepatocellular carcinoma.