It has also been shown that transfection of OSCC cell lines with Cornulin resulted in the reduction of proliferation of those cell lines with their arrest in the G1 phase of the cell [15] and that silencing Cornulin expression leads to improper G1 to S phase transition [5], thereby suggesting its role as a tumor suppressor gene due to its involvement in cell cycle regulation and prevention of tumorigenesis. The gene discussed is CRNN; the disease is neoplasm.