The National Evaluation of the Frequency of Renal Impairment co-existing with NIDDM (NEFRON) found that 55% of subjects with CKD had normal albumin excretion in T2DM [18]. In Third National Health and Nutrition Examination Survey (NHANES III), 1197 subjects with T2DM and low eGFR (<60ml/min) were present in 30% of subjects in the absence of micro- or macro albuminuria and retinopathy [19]. These studies showed that the absence of albuminuria in T2DM subjects did not rule out DM as a cause of CKD. This evidence concerns the gene ALB and retinal disorder.