Meanwhile, KEGG analysis showed that these genes were mainly involved in VEGF signaling pathway (adjust P = 7.00E-05), AGE-RAGE signaling pathway in diabetic complications (adjust P = 2.32E-04), HIF-1 signaling pathway (adjust P = 2.97E-04), Insulin resistance (adjust P = 3.11E-03) and Alzheimer disease (adjust P = 7.36E-03) (Figure 8C). The gene discussed is HIF1A; the disease is early-onset autosomal dominant Alzheimer disease.