There is compelling evidence that the activity of β-and γ-secretase can regulate MAPK signal pathway (Salminen et al., 2016; Sochocka et al., 2017; Benito-Cuesta et al., 2020), neuronal apoptosis and phosphorylation of APP and Tau participate in the pathogenesis of AD (Kim and Choi, 2010). Here, APP is linked to Alzheimer disease.