BDNF and Alzheimer disease: The removal of aging cells by drug and genetic methods can reduce the brain Aβ load and tau disease, and improve the memory (Bussian et al., 2018; Musi et al., 2018; Zhang et al., 2019; Tam and Ju, 2022) of these AD model mice, Not only that, the study found that people with strong resilience to AD showed a unique cytokine spectrum (McKay et al., 2019), including higher levels of anti-inflammatory cytokines and neurotrophins, as well as lower levels of chemokines (Perez-Nievas et al., 2013; Barroeta-Espar et al., 2019).