PSEN2 and Alzheimer disease: Twelve targets were identified by PPI network analysis, while 5 targets AKT1, MAPK8, BCL2L1, FOXO3 and CTNNB1 were positively correlated with AD pathogenic genes APP, PSEN2 and MAPT, and associated with aging genes Our findings suggest that MAPK8, FOXO3 and CTNNB1 have clinical research value.