PSMA5 and Alport syndrome: Characteristic finding on kidneybiopsy in patients with Alport Syndrome is splitting of the glomerular basementmembrane on electron microscopy; immunofluorescence will show negative or nonspecificimmunoreactant deposition to collagen type IV, which can provide both diagnostic andprognostic information.[10] Skinbiopsy findings can reveal absence of the alpha-5 chain of Type IV collagen viainability of monoclonal antibody to bind against the protein.[10,165,176]