Jarrin et al. (13) summarized the potential mechanisms related to insomnia and hypertension, suggesting that insomnia may cause persistent hypertension through (but are not limited to) the activation of the autonomic nervous system (e.g., hyperactive sympathetic, lower parasympathetic), the renin-angiotensin-aldosterone system, the hypothalamic-pituitary-adrenal axis, and the immune system. The gene discussed is REN; the disease is insomnia.