For non-ε4 carriers, Cardona et al. (47) conducted a study on the correlation between ApoE allele and urate renal excretion in 68 patients with gout and 50 healthy controls, and found that the levels of TG and VLDL were significantly escalated in ApoE2 patients, while renal urate excretion was reduced that could be mediated by high levels of VLDL and ApoE2. This evidence concerns the gene APOE and gout.