Multivariate analysis of ApoE genotype showed that after adjusting for age, gender, heart rate, dyslipidemia, hypertension, diabetes, eGFR, history of receiving ACEIs/ARBs/β-blockers/statins, and smoking status, the risk of LVH decreased in the ε4 carriers [odds ratio (OR) = 0.94, 95% confidence interval (CI): 0.890–0.992, P = 0.025] and increased in the non-ε4 carriers (OR = 1.03, 95% CI: 1.005–1.049, P = 0.016) as serum UA level increased (for every increase of 10 μmol/L). The gene discussed is APOE; the disease is diabetes mellitus.