Associated cardiovascular diseases include diabetes (PDLIM5, HDAC4, and TLE1) (31, 35, 37), cardiac development (PDLIM5) and myocardial aging (CASP12), hypertension (PFKP and TAB2) (31–33, 36), and intracerebral and intraventricular bleeding (RUNX1) and stroke (AXIN2) (24, 27). Here, CASP12 is linked to diabetes mellitus.