KEGG analysis of glioma database showed that the PLK4-related gene is mainly enriched in “P53 signaling pathway”, “T cell and B cell receptor signaling pathways”, “cell cycle”, “mismatch repair” and “PD-L1 expression and PD-1 checkpoint pathway in cancer” (Supplementary Figures 6C, F, I). Here, CD274 is linked to central nervous system cancer.