Consistently, prognostic cox regression analysis using the TCGA database also indicated that high PLK4 levels in a variety of tumors, including LUAD, LIHC, pan-kidney cohort (KIPAN), mesothelioma (MESO), LGG, glioma (GBMLGG), KIRP, PRAD, pheochromocytoma and paraganglioma (PCPG), ACC, and KICH, were associated with OS, DFS, disease free interval (DFI) and progression free interval (PFI) (Figures 4C–F). Here, PLK4 is linked to central nervous system cancer.