They demonstrated that exosomal miR-549a could reduce the expression level of hypoxia-inducible factor 1 alpha subunit (HIF1α) by binding to the 3’-UTR region of HIF1α mRNA, which in turn attenuate tumor angiogenesis and endothelial cell migration in ccRCC (31). Here, HIF1A is linked to nonpapillary renal cell carcinoma.