Among them, BRAF variations occur in 66% of melanomas (22), which can lead to metabolic reprogramming (23).The most frequent BRAF mutation is BRAFV600E, where the 600th valine position of the BRAF mutation is replaced by glutamate (BRAFV600E), leading to constitutive activation of its serine/threonine kinase activity (24). This evidence concerns the gene BRAF and melanoma.