Inhibition of LDH induced by oxalate and dichloroacetic acid can inhibit the growth of melanoma (96), and inhibition of LDHA improves the efficacy of anti-PD-1 treatment since the downregulation of tumor LDHA inhibits lactate production and saves glucose, and then improves the tumor microenvironment, resulting in increased T cell infiltration. Here, PDCD1 is linked to melanoma.