MYC and melanoma: Another crucial element influencing melanoma glycolysis is c-Myc (40), which is a member of the MYC proto-oncogene family (c-Myc, L-Myc, and N-Myc are collectively known as MYC) that encodes the helix-loop-helix leucine zipper (bHLHZip) transcription factor (48, 49).