PDCD1 and melanoma: In contrast, although OXPHOS-dependent melanomas have more glucose, melanoma cells with high oxidative phosphorylation flux consume more oxygen, and the hypoxic microenvironment is more likely to cause T cell dysfunction (113), accounting for the shorter overall survival of patients with high oxidative phosphorylation flux than those with high glycolytic flux after PD-1 monoclonal antibody treatment.