In addition, the AUC of GAADPB for differentiating HCC from CHB and HC subgroups was 0.946 and 0.991, respectively, which was similar to the performance of GALAD (AUCCHB=0.954, P=0.453; AUCHC=0.991, P= 0.857) and significantly higher than that of AFP (AUCCHB= 0.879, P=0.003; AUCHC=0.953, P=0.005) and DCP (AUCCHB=0.871, P=0.009; AUCHC=0.94, P=0.001). The gene discussed is ACE; the disease is hepatocellular carcinoma.