KDM2A and clear cell renal carcinoma: A recent report showed that NUF2 promotes clear cell renal cell carcinoma progression through epigenetic activation of high-mobility group AT-hook 2 (HMGA2) transcription by suppressing lysine demethylase 2A (KDM2A) expression and affecting its occupancy on the HMGA2 promoter region to regulate histone H3 lysine 36 di-methylation (H3K36me2) modification (41).