STAT3 and neoplasm: We found that Hallmarks of tumor such as “epithelial-mesenchymal transition (EMT)”, “TGF-β pathway”, “Apical junction”, “Angiogenesis”, “Hypoxia”, “Hedgehog pathway”, “TNFα/NF-κB pathway”, “Inflammatory response”, “Wnt/β-catenin pathway”, and “IL6 jak stat3” were dynamically enriched in samples with high expression of Mena (Figure 3D).