For example, increased NFE2L2 and TMB pathway changes were linked to radiation resistance in laryngeal squamous cell carcinoma (LSCC) (26), and NLRP3 activation could promote carcinogenesis and chemoresistance in HNSCC (27, 28), and ATP7B upregulation promoted chemoresistance of HNSCC (29). The gene discussed is NFE2L2; the disease is head and neck squamous cell carcinoma.