Mechanistically, it has been shown that NLRP3 inflammasome-mediated inflammatory responses are activated in T2DM animals with OSA as well as cell models, which may be related to MALT1 overexpression leading to inhibition of miR-224-5p in the hippocampus (Du et al., 2020). The gene discussed is NLRP3; the disease is obstructive sleep apnea syndrome.