In the pathogenesis of AMD, the previously described in vivo and in vitro studies by Lansel et al. (1998); Marti et al. (1998); Miller et al. (2006) analyzing the associated photoreceptor degeneration, show contradictory results concerning the role of a p53-related photoreceptor cell death. The gene discussed is TP53; the disease is age-related macular degeneration.