KCNK2 and heart disorder: While the physiological role of TREK-1 has not been proven formally, some cardiac diseases have been shown to be associated with changes in TREK-1 expression and the implication of TREK-1 can be inferred based on its electrophysiological properties or even proved by restoration of the initial expression (Zhao et al., 2011; Benoist et al., 2014; Lugenbiel et al., 2017; Kamatham et al., 2019; Dragasis et al., 2022).