Subsequently, fundamental studies by Guzik et al. revealed that T-lymphocytes were essential in the development of hypertension and related vascular dysfunction mice models (Guzik et al., 2007) and cytotoxic CD8+ T cells lead to renal vascular remodeling and Na+ retention in hypertension (Trott et al., 2014). This evidence concerns the gene CD8A and hypertensive disorder.