CASP1 and Hypertension: Hyperhomocysteinemia, a risk factor for the development of hypertension and its complications (Skeete and DiPette, 2017), has been shown to induce NLRP3 inflammasome assembly, caspase-1 activation and pyroptosis in endothelial cells, while mice deficient in caspase-1 or NLRP3 are protected (Xi et al., 2016).