IL17A and psoriasis: By administering rTpp53 on the skin of the IMQ-induced psoriasis mouse, we investigated the effects of rTpp53 treatment on the alleviation of psoriasis, the expression of cytokines related to the IL-23/IL-17 axis in the psoriatic skin, the expression of keratinocyte-producing cytokines, chemokines and AMPs, and the direct effect on splenocytes and macrophages.