Although we found, in this study, rTpp53 to exert the suppressive effect on Th 17 response, it is necessary to further investigate its effect on psoriasis-related signal pathways such as NF-κB, TNF-α, JAK/STAT, Bruton’s tyrosine kinase, oxidation, and IL-2-inducible T-cell kinase-related signal pathways to reveal the detailed mechanism of the amelioration of psoriasis by rTpp53. This evidence concerns the gene TNF and psoriasis.