Upon stimulation and the effect of the feed-forward mechanism, keratinocytes in the skin produce various kinds of cytokines (Il36, Il1b, Ill17c, Il22, and Il8), chemokines (Ccl2, 3, 5, 17, 20, 22, and Cxcl1, 2, 5, 9, 10, 11), and AMPs (S100a7, S100a8, S100a9, Defb4, Defb14, Lcn2, and Camp), which play critical roles in the pathogenesis of psoriasis. This evidence concerns the gene S100A8 and psoriasis.