These collective findings demonstrate that immune protection can be achieved with either CD4+ or CD8+ T cells, but eliciting memory responses proximal the site of infection, e.g., the stimulation of TRMs, are more apt to protect, possibly preventing or limiting brucellae dissemination as suggested by the ΔznuA B. melitensis (Clapp et al., 2016), znBAZ (Wang et al., 2020), and znBM-mC (Goodwin et al., 2022) studies. This evidence concerns the gene CD4 and infection.