ERBB2 and neoplasm: After demonstrating proof of concept in various HER2-expressing in vitro cell lines, the AffiHER2OMVsiRNA was infused into a tumor xenograft murine model and after multiple injections and a number of days, it was found the group of mice receiving the targeted drug-loaded OMV displayed tumor growth inhibition of 66% as compared to the vehicle control (Gujrati et al., 2014).