No significant association effect was found between mechanism of ischemic stroke [measured by TOAST (23) classification], vascular territory, onset to puncture time, NIHSS on admission, early ischemic changes on CT [ASPECT (24)], use of CT perfusion (CTP), angiographic collaterals status [ASTIN/SIR (25)] scores at admission, administration of IV-tPA or incidence of wake-up strokes (Table 2). The gene discussed is PLAT; the disease is ischemic stroke.