More specifically, we found that ten genes of interest — ACSM5, ADAM28, ANKFN1, CCDC163P, COLCA1, FMNL3, LOC105371645, NPL, ORAI3, and RIN2 — that distinguished the transcriptional patterns in the hippocampus of female TBI donors presenting with dementia compared to controls presenting with dementia and to TBI samples not presenting with dementia. The gene discussed is ACSM5; the disease is dementia.