Interestingly, seven of the ten genes of interest identified in our PCA — including NPL, LOC105371645, ADAM28, COLCA1, ACSM5, RIN2, and ANKFN1 — showed statistically significant positive correlations with MCP-1 concentrations in the hippocampus of female TBI donors presenting with dementia. The gene discussed is ANKFN1; the disease is dementia.