In conclusion, this study indicated that miR-15a-5p, miR-147a, miR-192-5p, miR-197-3p, miR-532-5p, and miR-650 might participate in NF-κB signaling pathway by co-targeting TRAF5 and affect the apoptosis and signal transduction of DLBCL. This evidence concerns the gene TRAF5 and diffuse large B-cell lymphoma.