NLRP3 and colorectal carcinoma: Moreover, NLRP3 was found highly expressed in CRC tissues and mesenchymal-like CRC cells, and promoted epithelial-mesenchymal transition (EMT) in an inflammasome-independent way; knockdown of NLRP3 in CRC cells decreased cell proliferation, migration and invasion ability (Wang et al., 2016; Shao et al., 2020; Shi et al., 2021b; Marandi et al., 2021).