Daley et al. (2017) reported that the activation of NLRP3 inflammasome in macrophages directs tolerogenic T cell differentiation, which would induce immunological tolerance and promote pancreatic tumor growth. Hu et al. (2018) showed that down-regulated NLRP3 signaling in pancreatic cancer cells would suppress progression of pancreatic cancer and decrease epithelial-mesenchymal transition-induced cell invasion. Here, NLRP3 is linked to pancreatic neoplasm.