NLRP3 and familial pancreatic carcinoma: In the pancreas, NLRP3 activation was found to be necessary for the development of experimental acute pancreatitis, pancreatic fibrosis, obesity-induced insulin resistance, and to be a critical inflammatory mechanism in pancreatic cancer (Vandanmagsar et al., 2011; Wan et al., 2016; Boone et al., 2019; Li et al., 2020b; Das et al., 2020; Sendler et al., 2020; Tang et al., 2020; Gao et al., 2021).