And in Sonohara’s research, the adjacent tissue of HCC was reported to be in a hyper-inflammatory state due to the overexpression of NLRP3, NLRC4, and AIM2 genes, which was showed to be closely related to poor overall survival, suggesting that the high expression of NLRP3 may become an independent prognostic factor for overall survival after surgery in HCC (Sonohara et al., 2017). This evidence concerns the gene AIM2 and hepatocellular carcinoma.