NLRP3 was reported to play essential roles in the pathogenesis of alcohol-associated liver disease, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, cirrhosis and fibrosis, which ultimately leads to hepatocellular carcinoma (HCC) (Wei et al., 2014; Wree et al., 2014; Mridha et al., 2017; Luan et al., 2018; Pourcet et al., 2018; Chen et al., 2020; Tao et al., 2020; Xie et al., 2020; Surlin et al., 2021). The gene discussed is NLRP3; the disease is hepatocellular carcinoma.