However, according to the study of West et al., in gp130 F/F mouse model, NLRP3 expression levels did not affect the development of gastric tumors, and the cellular processes associated with tumorigenesis in the gastric mucosa, such as proliferation, apoptosis, and inflammation did not changed in the NLRP3 knockout gp130 mouse, which suggested that NLRP3 might not play a major role in promoting inflammasome-driven gastric tumorigenesis (West et al., 2022). The gene discussed is NLRP3; the disease is gastric neoplasm.