NLRP3 and pancreatic ductal adenocarcinoma: In Liu’s study, NLRP3 was reported to be upregulated in pancreatic ductal adenocarcinoma (PDA), as shown in both infiltrating immune cells and tumor cells; and the activation of NLRP3 inflammasome in macrophages would induce immunological tolerance and promote the tumor growth (Liu et al., 2020).