INS and central nervous system cancer: They confirmed the presence of uveal melanoma-specific exosomes in hepatic circulation and determined the expression of miRNAs (hsa-miR-370, hsa-miR-210, hsa-miR-320a, hsa-miR-124, hsa-miR-107 and hsa-miR-486-5p) typical for patients’ samples and melanoma cell lines, involved in the regulation of cancer-related pathways (melanoma, prostate and glioma), hedgehog signaling, insulin signaling and focal adhesion, similar to our findings (Eldh et al., 2014).