To investigate the underlying mechanism of the lncRNA HOTAIR in RB development, Fu et al., (Fu et al., 2022), showed that HOTAIR was the upregulated in RB cells (ORB50, Y79, HXO-RB44, and WERI-RB) in comparison with normal retinal cells (ARPE-19 and RPE-1). This evidence concerns the gene RB1 and retinoblastoma.