E2F5 and cancer: E2F5 may be involved in the development of other cancers, such as hepatocellular carcinoma, colon, breast, ovarian, osteogenic sarcoma, and esophageal squamous cell carcinoma (Fuchs et al., 2001; Lassmann et al., 2007; Umemura et al., 2009; Kothandaraman et al., 2010; Jiang et al., 2011).