Specifically, a lack of glucose has been shown to dampen the inflammatory signaling mediated by mTOR and IFN-ɣ in the CD8+ population, leading to tumor progression (Chang et al., 2015) The glycolytic pathway is historically known to be typically high in proliferating cells(Warburg, 1956), and more recently analysis obtained from patient data reported an inverse correlation comparing upregulation of glycolysis genes in the tumor and T cell infiltration (Cascone et al., 2018). The gene discussed is CD8A; the disease is neoplasm.