Among them, essential pathways include the AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, fluid shear stress and atherosclerosis, IL-17 signaling pathway, TNF signaling pathway, Chagas' disease, prostate cancer, hepatitis B, Kaposi's sarcoma-associated herpesvirus infection, and chemical carcinogenesis-receptor activation (Figure 6 and Supplementary Figure 1). The gene discussed is TNF; the disease is hepatitis B virus infection.