Despite the lack of evidence for increased susceptibility to chronic neurological diseases such as PD after SARS-CoV-2 infection, it can be postulated that SARS-CoV-2 infection could predispose patients to long-term neurological disorders via dysfunction of ACE-2, compromising the integrity of the intestinal barrier leading to elevated levels of circulating lipopolysaccharides (LPS), and subsequent formation of α-synuclein (α-Syn) deposits in enteric nerves. Here, ACE2 is linked to Parkinson disease.