Moreover, Z-DNA-binding protein 1 (ZBP1), a novel effector of necroptosis, triggers NLRP3 inflammasome activation and release of IL-1β through the RIPK1-RIPK3-Caspase-8 axis during influenza A virus (IAV) infection (Huang et al., 2021). The gene discussed is CASP8; the disease is influenza.