TLR4 and ischemia: As shown in Figure 1b and c and Table 1 and Table S1, rats that developed tonic-clonic seizures after ischemia showed significantly more TLR4-positive cells than the Sham group (77.6 ± 3.20 vs 58.6 ± 1.24, p < 0.05, n = 5 per group).