In breast cancer, the levels of IL1β (median 95.45; range, 84.80–113.8) and VEGF (median 237.0; range, 209.5–255.6) were significantly increased compared to healthy individuals IL-1β (median 81.45; range, 71.20–100.2) and VEGF (median 187.0; range, 152.3–243.1), while BC serum concentration of IL-4 (median 139.1; range, 120.2–207.9) was significantly decreased compared with control group IL-4 (median 217.2; range, 149.9–243.2) (Fig. 2). This evidence concerns the gene IL4 and breast cancer.