Furthermore, phosphorylation at Ser422 in the tau protein, which is often identified as one of the early pathological phosphorylation sites in various tauopathies (Guillozet-Bongaarts et al., 2006; Vana et al., 2011; Collin et al., 2014; Tiernan et al., 2016), increased significantly by 32.50% only in the case line (Figures 2A, C and Supplementary Table 1). Here, MAPT is linked to tauopathy.