We also observed reductions in neuronal activity and elevations in the levels and pathological phosphorylation of tau, a microtubule-associated protein that goes awry in a number of neurodegenerative disorders that involve cognitive deficits (Bodea et al., 2016; Kanaan et al., 2016; Wang and Mandelkow, 2016; Yates et al., 2021). The gene discussed is MAPT; the disease is Cognitive impairment.