Finally, variants in TMEM106B have been shown to be associated with risk in several aging-related diseases in addition to ALS/FTD, including Parkinson’s disease, Alzheimer’s disease, and limbic-predominant age related TDP-43 encephalopathy (LATE) neuro-pathological change (LATE-NC) with or without coexisting hippocampal sclerosis pathology, and may in fact confer a neuronal protection effect against general aging independent of disease status (Satoh et al., 2014; Nelson et al., 2019; Tropea et al., 2019; Li et al., 2020). Here, TMEM106B is linked to frontotemporal dementia.