Genetic variants in transmembrane protein 106 B (TMEM106B) are genetic modifiers of frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) in patients with pathological G4C2 hexanucleotide expansions in C9orf72 (Van Deerlin et al., 2010; Vass et al., 2011; Gallagher et al., 2014; van Blitterswijk et al., 2014). Here, C9orf72 is linked to frontotemporal dementia.