During an antigen rechallenge, rapid production of IL-4 occurs, which causes apoptosis of neonatal Th1 cells through the formation of heteroreceptor IL-4Rα/IL-13Rα1, which together with regulatory T cells takes part in the control over peripheral tolerance and restrains autoimmunity in adults (Barik et al., 2017). Here, IL13RA1 is linked to Autoimmunity.