IGFL2 and Alzheimer disease: Comparing lesional PN skin to lesional AD skin and control skin, the significantly upregulated DEGs in PN included matrix metalloproteinases (MMP1, MMP3, MMP10, MMP13), OSM, NGF, IL1α, IL1β, CXCL2, CXCL8, and insulin-like growth factors (IGFL2, IGFL3) (Figure 2D and Supplementary Figure 1B).