The Cancer Genome Atlas (TCGA) has previously identified four distinct molecular signatures in endometrial cancer—termed POLE-mutated/ultramutated (POLEmt), microsatellite-instable/hypermutated (MSI), copy-number-high/p53-mutated (p53mut), and no specific molecular profile (NSMP) (25)—with prognostic implications. This evidence concerns the gene POLE and endometrial cancer.