BRAF and non-small cell lung carcinoma: Over 40 missense mutations have been discovered in human, while the most common BRAF mutation occurs in exon 15 is a thymidine to adenosine transversion at the level of T1799A, leading to the valine to glutamate substitution at codon 600 (V600E), which contribute to approximately half of the BRAF-mutant NSCLC (65, 66).